MPS IV: Validation and Applications
Massively parallel sequencing (MPS) is an exciting technology that holds promise for enhancing the capabilities of the forensic DNA analyst. However, there are several challenges that confront implementation of an MPS system into the crime laboratory, which include: training and education on fundamentals of the chemistry, functionality, and genetic marker systems; validation criteria and study design; policy and data procedure developments related to CODIS operations; and perceived admissibility and privacy issues. This four-part webinar series will address these and other areas of interest, providing foundational information on the two available MPS systems, covering platforms and chemistries, throughput, genetic markers, bioinformatics, validation requirements, applications, and potential admissibility issues. In this fourth webinar, Validation and Applications, the discussion focus on the potential validation requirements needed to derive resolutions to pending issues of MPS implementation, including legality and CODIS considerations. Successful examples of MPS application and lessons learned from previous technology platforms are highlighted in order to determine the next steps for forensic adoption.